3-ketosteroid isomerase

The fetal adrenal cortex lacks expression of the enzyme early on, thus mineralocorticoids (. aldosterone ) and glucocorticoids (. cortisol ) cannot be synthesized. This is significant because cortisol induces type II pneumocytes of the lungs to synthesize and secrete pulmonary surfactant ; without pulmonary surfactant to reduce the alveolar surface tension , premature neonates may die of neonatal respiratory distress syndrome . If delivery is unavoidable (. because of placental abruption , or pre-eclampsia / HELLP syndrome ), then glucocorticoids (. cortisol) can be administered.

Fellow, Society for Risk Analysis

Outstanding Service Award, Society for Risk Analysis, 2012

Senior Fellow, Department of Epidemiology, University of Washington, 1976–1977

Postdoctoral Fellow, Departments of Pharmacology and Biophysics, Johns Hopkins Medical School, Baltimore, Maryland, 1966-1968

Elected Member, American Epidemiological Society

Distinguished Achievement Award, Society for Risk Analysis, 2001

Founders’ Award, Chemical Industry Institute of Toxicology, 1990

Lester R. Ford Award of Mathematical Association of America, 1977

Faculty Research Fellowship of Indiana University, 1974–1976

3-ketosteroid isomerase

3-ketosteroid isomerase


3-ketosteroid isomerase3-ketosteroid isomerase