Adrenal cortex steroid synthesis

Depletion and dysregulation of adrenal hormones such as cortisol and adrenaline are the primary symptomatic drivers of Adrenal Fatigue and crashes. Repeated crashes over time will invariably further weaken the adrenal glands. While the intensity of each crash will increase as Adrenal Fatigue increases, it is not a linear progression clinically. Many in Stage 1 and Stage 2 Adrenal Fatigue are not aware of their impending problems. Their daily activities will remain unchanged, as there is sufficient adrenal reserve to compensate for any transient energy low.


--- Stress is often mentioned by CSS patients around the time of their diagnosis, and in a way this seems related to the adrenal glands as well. A patient in another support group reported reading in "The Stress of Life" by Dr. H. Seyle:.... "the adrenal glands are the processors of stress in our bodies. A person's stress resistance will vary with the competence of his adrenals. Continually stressing them, finally depletes them. When we become exhausted by life, on a mental or physical level, our adrenal glands often fail to keep up, and illness ensues".

Withania Somnifera:  Another Ayurvedic herb, Ashwagandha, aka Indian Ginseng, rivals that of Panax. Ginseng  in the amount of positive data available. It shows adaptogenic properties both in attenuating stress perception, altering cortisol, and increasing TTE (time to exhaustion) in trained athletes. The potentially active constituents of ashwagandha include alkaloids and steroidal lactones that together are called withanolides (particularly withaferin A), and preparations are often standardized to their percentage contents of withanolides, as with the trademarked Sensoril brand.

Beyond the management of cortisol levels, there are other steps you can take to increase the likelihood of a solid night's sleep. As mentioned above, one of the most common reasons for waking during the night is the need to urinate. Seeing that you are well-supplied for sodium is very important in this regard. At my clinic, I recommend liberal use of unrefined sea salt for most individuals with adrenal fatigue. Magnesium supplements and a moderate amount of potassium should also help with hydration, and allow you to hold onto the water more effectively. Magnesium is also a muscle relaxant and a potent inducer of deeper sleep – it is no generalisation to say that almost everyone needs more magnesium, regardless of adrenal function or hydration.

Adrenal cortex steroid synthesis

adrenal cortex steroid synthesis

Beyond the management of cortisol levels, there are other steps you can take to increase the likelihood of a solid night's sleep. As mentioned above, one of the most common reasons for waking during the night is the need to urinate. Seeing that you are well-supplied for sodium is very important in this regard. At my clinic, I recommend liberal use of unrefined sea salt for most individuals with adrenal fatigue. Magnesium supplements and a moderate amount of potassium should also help with hydration, and allow you to hold onto the water more effectively. Magnesium is also a muscle relaxant and a potent inducer of deeper sleep – it is no generalisation to say that almost everyone needs more magnesium, regardless of adrenal function or hydration.

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