Reproductive Toxicology Studies: A study in CD-1 mice given albuterol sulfate subcutaneously showed cleft palate formation in 5 of 111 (%) fetuses at mg/kg (less than the maximum recommended daily inhalation dose for adults on a mg/m 2 basis) and in 10 of 108 (%) fetuses at mg/kg (approximately 8 times the maximum recommended daily inhalation dose for adults on a mg/m 2 basis). The drug did not induce cleft palate formation at a dose of mg/kg (less than the maximum recommended daily inhalation dose for adults on a mg/m 2 basis). Cleft palate also occurred in 22 of 72 (%) fetuses from females treated subcutaneously with mg/kg of isoproterenol (positive control).
Also, medical advice should be sought if the person has previously suffered heart attack, has a disease of the blood vessels or the heart, has high cholesterol levels in the blood, has clotting or excess bleeding problems, or has diabetes, kidney, or liver diseases. If the person has one or more of these problems, then an alteration of the dosage may be required. Medicines that can react with Winstrol are blood thinners or anticoagulants, diabetes medication, and insulin. Care should be taken while administering Winstrol with any of these medicines.
Whether airway hyperresponsiveness is a symptom of airway inflammation or airway remodeling, or whether it is the cause of long-term loss of lung function, remains controversial. Some investigators have hypothesized that aggressive treatment with anti-inflammatory therapies improves the long-term course of asthma beyond their salutary effects on parameters of asthma control and rates of exacerbation over time. 13 This contention has been supported by an observational study 14 that found long-term exposure to ICS was associated with an attenuation of the accelerated decline in lung function previously reported in asthmatics; more studies are required to substantiate these findings.