Fluocinonide is one of the most effective topical medications to cure tongue sore. This medication can be found in the form of a cream, gels, or ointment. Still, patients who use this medication should be cautioned that the chronic use of topical medication can result in side effects such as mucosal atrophy in addition to general absorption of the steroid medication. Patients should be warned not to apply topical medications virally. Topical steroid treatments are not supposed to go beyond two weeks of any possibility of aphthous ulcers.