Corticosteroids function of the hormone

Thyroid storm is a life-threatening condition of the hyperthyroid state. 26 It most commonly occurs in patients with Graves' disease but may also occur in those with multinodular goiter or toxic adenoma. 27 It is treated by correcting the hyperthyroidism and treating the precipitating events. 26 Correction of the hyperthyroid state involves using drugs such as propylthiouracil or methimazole (Tapazole), beta blockers or corticosteroids, which decrease the peripheral effects of thyroid hormone and the conversion of thyroxine (T 4 ) to the more potent triiodothyronine (T 3 ). 22 , 26 Dexamethasone can be used for that purpose, at a dosage of 2 mg intravenously every six hours, and can eventually can be switched to an oral dosage of 2 mg every six hours. 28

There are two major types of hormones produced by the adrenal gland , the mineralocorticoids and the glucocorticoids. This monograph discusses prednisone which is a synthetic glucocorticoid or corticosteroid. There are many different corticosteroid drugs available and different medical conditions are treated with different corticosteroid drugs based on the individual drug’s pharmacology (potency, speed of onset, duration of action). The other types of hormones produced by the adrenal gland are called mineralocorticoids. They primarily control salt and water balance in the body.

Long-acting corticosteroids improve lung function by suppressing inflammation in the respiratory passages and help reduce the need for oral medication. Types of long-acting corticosteroids and their usual daily dosages pinclude the following:

  • Aerospan (flunisolide HFA)—2 inhalations 2x/day
  • Alvesco (ciclesonide)—1-2 inhalations 2x/day
  • Asmanex Twisthaler (mometasone)—1 inhalation 2x/day or 2 inhalations 1x/day
  • Flovent HFA (fluticasone)—1-4 inhalations 2x/day
  • Pulmicort Flexhaler (budesonide)—1-2 inhalations 2x/day
  • QVAR (beclomethasone)—1-4 inhalations 2x/day

Certain drugs such as troleandomycin (TAO), erythromycin ( Ery-Tab , EryPed 200), and clarithromycin ( Biaxin ) and ketoconazole ( Nizoral ) can reduce the ability of the liver to metabolize (breakdown) corticosteroids and this may lead to an increase in the levels and side effects of corticosteroids in the body. On the other hand, phenobarbital, ephedrine , phenytoin ( Dilantin ), and rifampin ( Rifadin , Rimactane ) may reduce the blood levels of corticosteroids by increasing the breakdown of corticosteroids by the liver. This may necessitate an increase of corticosteroid dose when they are used in combination with these drugs.

There is little evidence as to what percentage of a topical corticosteroid dose is absorbed systemically. Studies investigating systemic effects do not measure how much of the corticosteroid is in the blood, but instead focus on measuring cortisol as a marker of hypothalamic-pituitary-adrenal (HPA) axis suppression. After a few weeks’ treatment with potent or very potent topical corticosteroids temporary HPA axis suppression does occur. However, this resolves upon cessation of the topical corticosteroid, without the need for dose tapering. 5, 19 HPA axis suppression is more marked when topical corticosteroids are applied under occlusion, . with wet wraps.

Corticosteroids function of the hormone

corticosteroids function of the hormone

Certain drugs such as troleandomycin (TAO), erythromycin ( Ery-Tab , EryPed 200), and clarithromycin ( Biaxin ) and ketoconazole ( Nizoral ) can reduce the ability of the liver to metabolize (breakdown) corticosteroids and this may lead to an increase in the levels and side effects of corticosteroids in the body. On the other hand, phenobarbital, ephedrine , phenytoin ( Dilantin ), and rifampin ( Rifadin , Rimactane ) may reduce the blood levels of corticosteroids by increasing the breakdown of corticosteroids by the liver. This may necessitate an increase of corticosteroid dose when they are used in combination with these drugs.

Media:

corticosteroids function of the hormonecorticosteroids function of the hormonecorticosteroids function of the hormonecorticosteroids function of the hormonecorticosteroids function of the hormone

http://buy-steroids.org