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Results Among 140 randomized patients (mean age, 58 [SD, 8] years, 75 women [54%]), 119 (85%) completed the study. Intra-articular triamcinolone resulted in significantly greater cartilage volume loss than did saline for a mean change in index compartment cartilage thickness of − mm vs − mm (between-group difference, − mm; 95% CI, − to − mm); and no significant difference in pain (− vs −; between-group difference, −; 95% CI, − to ). The saline group had 3 treatment-related adverse events compared with 5 in the triamcinolone group and had a small increase in hemoglobin A 1c levels (between-group difference, −%; 95% CI, −% to −%).