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Genetics play a role in the development of COPD. [9] It is more common among relatives of those with COPD who smoke than unrelated smokers. [9] Currently, the only clearly inherited risk factor is alpha 1-antitrypsin deficiency (AAT). [46] This risk is particularly high if someone deficient in alpha 1-antitrypsin also smokes. [46] It is responsible for about 1–5% of cases [46] [47] and the condition is present in about 3–4 in 10,000 people. [16] Other genetic factors are being investigated, [46] of which there are likely to be many. [11]

Estriol is the generic name of estriol in American English and its INN , USP , BAN , DCF , and JAN . [26] [1] [30] [31] It is pronounced / ˌ ɛ s t r aɪ oʊ l / ES - TRYE -ohl . [ citation needed ] Estriolo is the name of estriol in Italian [31] and estriolum is its name in Latin , whereas its name remains unchanged as estriol in Spanish , Portuguese , French , and German . [31] [1] Oestriol , in which the "O" is silent, was the former BAN of estriol and its name in British English , [26] [30] [1] but the spelling was eventually changed to estriol . [31]

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