Black seed oil has been shown to possess antiparasitic properties comparable to those of some of the leading pharmaceuticals. In one study, black seed oil was effective in reducing the number of Schistosoma mansoni worms in the liver and decreased the total number of ova deposited in both the liver and the intestine. Furthermore, it increased the number of dead ova in the intestinal wall and markedly reduced the granuloma diameters. Administration of black seed oil concomitantly with the leading flatworm pharmaceutical, lowered further the number of dead ova than was observed when the drug was given alone, indicating that the plant oil potentiates the action of the drug.
Seizures Nearly 15% of childhood epilepsy cases are resistant to treatment. Many of the drugs used to treat epilepsy produce unwanted side effects or are capable of producing serious adverse events. When epilepsy remains uncontrolled, it is termed refractory or pharmacoresistant. A recent study found black seed oil has anticonvulsant effects and improved seizure control in children suffering from refractory epilepsy. Earlier animal studies have also demonstrated the anticonvulsant effects of thymoquinone. Researchers hypothesized that thymoquinone may have anticonvulsant activity in petit mal epilepsy probably through an opioid receptor-mediated increase in GABAergic tone. They have also suggested black seed's potent antioxidant properties may be responsible for preventing seizures as well.