The immediate effects of AAS in the brain are mediated by their binding to androgen (male sex hormone) and estrogen (female sex hormone) receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the acute effects of AAS in the brain are substantially different from those of other drugs of abuse. The most important difference is that AAS are not euphorigenic, meaning they do not trigger rapid increases in the neurotransmitter dopamine , which is responsible for the “high” that often drives substance abuse behaviors. However, long-term use of AAS can eventually have an impact on some of the same brain pathways and chemicals—such as dopamine, serotonin, and opioid systems—that are affected by other drugs of abuse. Considering the combined effect of their complex direct and indirect actions, it is not surprising that AAS can affect mood and behavior in significant ways.
I get 2, 4 and 5 and I’m completely natural. I have had people accuse me of taking steroids many times and it pissed me off. It gets me to the point where I want to take steroids just so that I can say “Now this is me on steroids fckers!”. Lol. But nah I get a lot of acne outbreaks naturally and I have had many stretch marks as well as abnormally fast muscle gains. I’m a very lean person and when I stop working out I’m capable of drastically going from jacked to skinny as heck. When I start back up again I blow up quick. Another thing I’ve noticed is my pumps are naturally a lot more intense then the average lifter. Like my shoulders blow up like bowling balls and veins and shreds show up all over them along with my arm’s and chest. I’ve had a tone of people accuse me of taking steroids because of these factors. I also had a relative hug me once and say I was jacked and as solid as steal. He said only steroids do that. (He took steroids in the past) But it is to my understanding that muscle is solid… or at least a lot more solid than fat. At the time I was taking creatine and l-arginine with citrilline malate (which is a precursor to arginine) and a lot of BCAA’s.