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Use warm water or a squirt bottle to clean the irritated diaper area at every change, and let your child's bottom air out whenever possible. Before diapering, apply a thick coating of a zinc oxide-based cream to protect the rash from further moisture, which can make the rash even worse. You can also ask your doctor for advice about using a mild, topical steroid cream for more severe cases. If you suspect a yeast infection, see a doctor, who can prescribe an anti-fungal cream like over-the-counter clotrimazole (Lotrimin) or prescription nystatin to apply at every diaper change until the rash disappears. If your child has rashes in the diaper area that don't respond to conventional treatments, see your doctor to make sure the rash isn't related to another condition.