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Difluprednate has been shown to be embryotoxic (decrease in embryonic body weight and a delay in embryonic ossification) and teratogenic (cleft palate and skeletal anomalies) when administered subcutaneously to rabbits during organogenesis at a dose of 1-10 mcg/kg/day. The no-observed-effect-level (NOEL) for these effects was 1 mcg/kg/day, and 10 mcg/kg/day was considered to be a teratogenic dose that was concurrently found in the toxic dose range for fetuses and pregnant females. Treatment of rats with 10 mcg/kg/day subcutaneously during organogenesis did not result in any reproductive toxicity, nor was it maternally toxic. At 100 mcg/kg/day after subcutaneous administration in rats, there was a decrease in fetal weights and delay in ossification, and effects on weight gain in the pregnant females. It is difficult to extrapolate these doses of difluprednate to maximum daily human doses of Durezol, since Durezol is administered topically with minimal systemic absorption, and difluprednate blood levels were not measured in the reproductive animal studies. However, since use of difluprednate during human pregnancy has not been evaluated and cannot rule out the possibility of harm, Durezol should be used during pregnancy only if the potential benefit justifies the potential risk to the embryo or fetus.

Which made Canseco’s second benefactor — Mike Wallace — all the more important. John Hamlin, a producer at 60 Minutes , had gotten a tip about Canseco’s book from a friend at another network. (The friend couldn’t act on it because his employer was a Major League Baseball rights holder.) Hamlin began calling baseball people and confirming the details. Almost no one would talk on the record, but they suggested that Canseco’s account was true. One of the few allegations Hamlin couldn’t verify was Canseco’s insistence that Roger Clemens was juicing.

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