Combining the results of five randomised clinical trials randomising 499 patients with alcoholic hepatitis and/or cirrhosis demonstrated no significant effects of anabolic-androgenic steroids on mortality (relative risk (RR) , 95% confidence interval (CI) to ), liver related mortality (RR , 95% CI to ), complications of liver disease (RR , 95% CI to ), and liver histology. Further, anabolic-androgenic steroids did not significantly affect a number of other outcome measures. Anabolic-androgenic steroids were not associated with a significantly increased risk of non-serious adverse events but with the seldom occurrence of serious adverse events (RR , 95% CI to ).
But the potent and very potent topical steroids are more likely to be absorbed through the skin into the body and to cause side effects similar to oral steroids, particularly if they are used continuously for several months or on large areas of the body. These include bone thinning and an increased risk of osteoporosis. You should use topical steroids with care if you have dry, irritated or itchy skin, a skin infection, or if you are pregnant or breast feeding. Avoid using topical steroids on broken or infected skin, for treatment of rosacea, or if you have acne.